The Buzzword is idiopathic
Have you ever had a doctor say you have an idiopathic condition? This simply means that the doctors don’t know what has caused the disease. For example, a diagnosis of idiopathic hypersomnia would suggest that the cause of narcolepsy is unknown.
Often diseases that arise spontaneously can also be deemed idiopathic as the cause is likely unknown. If specialists don’t find a defined disease or cause while testing, they may define the condition as idiopathic “fill in complaint”.
Many conditions that were called idiopathic in the past are now known to be caused by specific genetic mutations/gene alterations. This also leads to improved treatments. For example, narcolepsy with cataplexy was considered idiopathic until it was discovered that the condition primarily occurs from loss of orexin, a key alerting neurochemical in the brain.